1961 is a year in the 20th century.
- January: Congo President Kasavuba arrests and assassinates Patrice Lamumbra. (TXF: "Musings of a Cigarette-Smoking Man")
- May 17 - May 20: Creighton Jones pulls off the road in Dudley, Arkansas to take a nap. He is discovered three days later insane and heavily disturbed by what he called "fire demons," most likely after encounter Walter Chaco and other cannibals.
- May 31: Dominican natives assassinate Rafael Trujilo. (TXF: "Musings of a Cigarette-Smoking Man")
- October 13: Future FBI Special Agent Fox William Mulder is born to William and Teena Mulder. (TXF: "Unusual Suspects"; "Kill Switch")