1988 is a year in the 20th century.
- FBI Special Agent Fox Mulder is assigned to the Violent Crimes Unit. (TXF: "Kill Switch") Soon after he writes a monograph that helps catch serial killer Monty Props. This catch makes Mulder very known in the Bureau as the best analyst in the Violent Crimes section. (TXF: "Pilot")
- There is an outbreak of hemmoraghic fever in Sacramento, California. The outbreak was kept under wraps by the Syndicate in order to avoid a panic. (TXF: "F. Emasculata")
- Nicholas Regali and Bob Harvey both serve a prison sentence in Walkill]. It was believed that they developed a friendship at this time. (TXF: "Release")