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- Charles Martin Smith as Dr. Osborne
- Dean Norris as US Marshal Tapia
- John Pyper-Ferguson as Paul
- William B. Davis as Cigarette Smoking Man
- Angelo Vacco as Angelo Garza
- Mitch Pileggi as Assistant Director Walter Skinner
- Morris Panych as Dr. Simon Auerbach
- Lynda Boyd as Elizabeth
- John Tench as Steve
- Alvin Sanders as Bus Driver