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- Gillian Anderson as Special Agent Dana Scully
- Robert Patrick as Special Agent John Doggett
- Annabeth Gish as Special Agent Monica Reyes
- Don Swayze as Terrance Pruit
- James McDonnell as Detective Van Allen
- Cyril O'Reilly as Ed Kelso
- Katy Boyer as Dr. Lisa Holland
- George D. Wallace as Dr. Bertram Mueller
- Kari Whitman as Roxanne