The Holy Spirit of God is the third person in the Holy Trinity according to most Christian beliefs.

According to Anthony Tipet, the Holy Spirit is comprised of two parts: one good part and one evil part, both of them equal. He believed that every human body was a clay shell made by God to hold the Holy Spirit. (TXF: "Via Negativa")

In 1983, Samuel Hartley believed he was briefly possessed by the Holy Spirit before raising a man from the dead. (TXF: "Miracle Man")

The Unholy Spirit was a vampire who perceived himself as a counterpart to the Holy Spirit in the Unholy Trinity. (TXF: "3")

In 1999, a Priest said a prayer, urging the grace of the Holy Spirit to prolong the life of Jordan Black. (MM: "Borrowed Time")