If one is attacked by a manitou, they become one. The manitou overcomes a man during the night, and not just during a full moon like the werewolf. When the blood lust of a man becomes uncontrollable, the manitou turns the man into a full, ravenous wolf-like creature. This cycle begins every night until death.
In 1994, Joseph Goodensnake, one of them, transformed into this beast and in that form did attack Lyle Parker, a settler and son of a farmer in the area. Caused by this "infection" he himself later attacks his own father, Jim Parker.